"I chose Moderna because it worked better in immunocompromised people after Johnson & Johnson," she says. ![]() But talk to your doctor about which might be best for you, Baker urges. The bonus of mixed brands is that early data shows that this approach may offer the best immune protection. And teaching your body new things - that's good." The vaccines all are trying to do the same thing, but each has their own way of doing it. "The new vaccine has to teach it a few more things, so you may get new side effects. "What may be happening is that the road map your body had for the first one is a little different with a changed vaccine," Baker says. A study in The Lancet showed that more people who received a mix of the Pfizer and AstraZeneca vaccines reported fever, chills, headache, joint pain and muscle aches than those who received a booster of the same brand, Karan points out. People who mix and match brands, however, may be more likely to be down for the count. And those who got the Moderna booster reported fewer reactions overall than after the second dose of the original (although unlike Pfizer, Moderna reduced its dose for the booster). ( Abnormal menstrual cycles and purple toe were among the lesser-known reactions on the first go-around.)įewer people have reported fevers after the Pfizer booster: 16.4% of participants in the second-dose study reported fever symptoms, compared with 8.7% of those in the booster study. No new side effects or adverse reactions showed up. After getting boosted, 63.7% of study participants experienced fatigue, 48.4% had headaches and 39.1% felt muscle pain. Indeed, side effects of the boosters are mimicking those of the initial doses, as you can see from the near-identical data that Pfizer submitted to the Food and Drug Administration after its studies: 61.5% of study participants developed fatigue, 54% had headaches and 39.3% dealt with muscle pain after getting Pfizer's second shot. But their immune systems are responding in other ways - albeit more gradually. Those receptors don't work as well in older people, so side effects could be less noticeable in them. ![]() One of those ways is by triggering certain receptors on immune cells, and that can result in fatigue, headaches and other common side effects, as observed in a small University of Pennsylvania study. That's because the vaccine provides protection in a few different ways. Your body's response might not do anything outwardly." "But if you don't, I wouldn't say it's not working. If you do get side effects, "at least you know it's working," says Charlotte Baker, a professor of epidemiology at Virginia Tech. That holds true for the boosters - which is especially good news in light of preliminary data showing that the Pfizer-BioNTech booster appears to work about as well against the omicron variant of the coronavirus as earlier doses did against earlier variants. ![]() If you don't have symptoms, "consider yourself lucky," Stanford University infectious disease physician Abraar Karan said in February. ![]() Paul Offit, an immunologist and the director of the Vaccine Education Center at Children's Hospital of Philadelphia, told NPR in April. "This is the first vaccine in history where anyone has ever complained about not having symptoms," Dr. You're in luck: Just as they did after the first round of shots, experts are quick to reassure that the vaccine works regardless of how you feel afterward. What's immune evasion? Epistasis?Īfter I got my initial COVID-19 vaccine, my head hurt and my muscles ached. Goats and Soda Coronavirus FAQ: Help me with omicron vocab.
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